| Type of Disease | Candidate Name | Indication | Discovery | Pre-clinical | Phase 1 | Phase 2 | Phase 3 |
| Metabolic Rare Disease | CBT-102 | Phenylketonuria (PKU) | |||||
| Autoimmune Diseases | CBT-104A | Inflammatory Bowel Disease (IBD) | |||||
| CBT-104B | Systemic lupus erythematosus (SLE) | ||||||
| CBT-104C | Rheumatoid Arthritis (RA) | ||||||
| CBT-104D | Graft-vs-Host Disease (GvHD) | ||||||
| New Project | CBT-10X | Colorectal Cancer |
| Candidate Name | MoA | Function | Address Health Need | Current Stage | Next Milestone |
| CBT-201 | Acetaldehyde Metabolism | Promote Acetaldehyde Degradation & Clearance | Hangover | Product Development | Market Test |
| CBT-202 | To be disclosed | To be disclosed | Smoking | Bacteria Strain Construction / Optimization | Animal Study |
| CBT-203 | To be disclosed | To be disclosed | Fat Metabolism | Bacteria Strain Construction | Candidate Strain Selection |
Engineered bacteria drug typically uses orally administered enteric capsules to increase convenience of intake
Bacteria is released in large or small intestine (depends on the indication), and performs therapeutic function
For inherited metabolic disorders (metabolic deficiencies), engineered bacteria can act as the metabolizing unit for harmful substances instead of human cell
Another type of engineered bacteria can secrete certain gene products (proteins, cytokines and etc.) to modulate the gut system and related biological processes (e.g immune system)
Through the therapeutic function of engineered bacteria, disease symptoms of patients are relieved
In many occasions, including business and social, people might feel compelled to consume alcohol and even participate in binge drinking
Alcohol (ethanol) is quickly metabolized by the liver into acetaldehyde, a highly toxic and carcinogenic substance. 40-60% of the Asian population cannot metabolize acetaldehyde properly due to gene deficiency
Due to acetaldehyde’s high toxicity, its accumulation in the body leads to hangover symptoms in the short-term, including headache, dizziness, flush, nausea and vomiting (upset stomach)
Acetaldehyde accumulation can damage different organs and tissues, such as liver, brain, cardiovascular system and etc., and thus leads to various diseases including cancer in the long term
We engineered an enzyme into a probiotic so it can quickly metabolize acetaldehyde in the gut and avoid accumulation. This way we not only can prevent hangover after heavy drinking, but also reduce the health risks of alcohol in the long term
CommBio Therapeutics Co., Ltd 沪ICP备2021004953号-1
